Cytochrome P450 RhF displays a high degree of substrate promiscuity, mediating a range of O-dealkylations, aromatic hydroxylations, epoxidations and asymmetric sulfoxidations. The self-sufficient nature of this CYP coupled with its ability to catalyse the oxidation of a wide range of functional groups highlights this enzyme as an excellent starting template for directed evolution and promising alternate to P450 BM3.
E. O'Reilly, M. Corbett, S. Hussain, P. P. Kelly, D. Richardson, S. L. Flitsch and N. J. Turner, Catal. Sci. Technol., 2013, 3, 1490 DOI: 10.1039/C3CY00091E
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