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Issue 6, 2013
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Substrate promiscuity of cytochrome P450 RhF

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Abstract

Cytochrome P450 RhF displays a high degree of substrate promiscuity, mediating a range of O-dealkylations, aromatic hydroxylations, epoxidations and asymmetric sulfoxidations. The self-sufficient nature of this CYP coupled with its ability to catalyse the oxidation of a wide range of functional groups highlights this enzyme as an excellent starting template for directed evolution and promising alternate to P450 BM3.

Graphical abstract: Substrate promiscuity of cytochrome P450 RhF

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Article information


Submitted
05 Feb 2013
Accepted
29 Mar 2013
First published
03 Apr 2013

Catal. Sci. Technol., 2013,3, 1490-1492
Article type
Communication

Substrate promiscuity of cytochrome P450 RhF

E. O'Reilly, M. Corbett, S. Hussain, P. P. Kelly, D. Richardson, S. L. Flitsch and N. J. Turner, Catal. Sci. Technol., 2013, 3, 1490
DOI: 10.1039/C3CY00091E

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