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Issue 23, 2013
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Recent advances in the chemoselective reduction of functional groups mediated by samarium(II) iodide: a single electron transfer approach

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Abstract

Recently, samarium(II) iodide reductants have emerged as powerful single electron donors for the highly chemoselective reduction of common functional groups. Complete control of the product formation can be achieved on the basis of a judicious choice of a Sm(II) complex/proton donor couple, even in the presence of extremely sensitive functionalities (iodides, aldehydes). In most cases, the reductions are governed by thermodynamic control of the first electron transfer, which opens up new prospects for unprecedented transformations via radical intermediates under mild regio-, chemo- and diastereoselective conditions that are fully orthogonal to hydrogenation or metal-hydride mediated processes.

Graphical abstract: Recent advances in the chemoselective reduction of functional groups mediated by samarium(ii) iodide: a single electron transfer approach

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Publication details

The article was received on 01 Jul 2013 and first published on 06 Sep 2013


Article type: Review Article
DOI: 10.1039/C3CS60223K
Citation: Chem. Soc. Rev., 2013,42, 9155-9183
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    Recent advances in the chemoselective reduction of functional groups mediated by samarium(II) iodide: a single electron transfer approach

    M. Szostak, M. Spain and D. J. Procter, Chem. Soc. Rev., 2013, 42, 9155
    DOI: 10.1039/C3CS60223K

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