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Issue 10, 2013
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Glycopolymer probes of signal transduction

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Abstract

Glycans are key participants in biological processes ranging from reproduction to cellular communication to infection. Revealing glycan roles and the underlying molecular mechanisms by which glycans manifest their function requires access to glycan derivatives that vary systematically. To this end, glycopolymers (polymers bearing pendant carbohydrates) have emerged as valuable glycan analogs. Because glycopolymers can readily be synthesized, their overall shape can be varied, and they can be altered systematically to dissect the structural features that underpin their activities. This review provides examples in which glycopolymers have been used to effect carbohydrate-mediated signal transduction. Our objective is to illustrate how these powerful tools can reveal the molecular mechanisms that underlie carbohydrate-mediated signal transduction.

Graphical abstract: Glycopolymer probes of signal transduction

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Article information


Submitted
08 Mar 2013
First published
18 Apr 2013

Chem. Soc. Rev., 2013,42, 4476-4491
Article type
Review Article

Glycopolymer probes of signal transduction

L. L. Kiessling and J. C. Grim, Chem. Soc. Rev., 2013, 42, 4476
DOI: 10.1039/C3CS60097A

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