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Issue 13, 2013
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Biomolecular hydration dynamics: a jump model perspective

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The dynamics of water molecules within the hydration shell surrounding a biomolecule can have a crucial influence on its biochemical function. Characterizing their properties and the extent to which they differ from those of bulk water have thus been long-standing questions. Following a tutorial approach, we review the recent advances in this field and the different approaches which have probed the dynamical perturbation experienced by water in the vicinity of proteins or DNA. We discuss the molecular factors causing this perturbation, and describe how they change with temperature. We finally present more biologically relevant cases beyond the dilute aqueous situation. A special focus is on the jump model for water reorientation and hydrogen bond rearrangement.

Graphical abstract: Biomolecular hydration dynamics: a jump model perspective

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Article information

05 Mar 2013
First published
23 Apr 2013

Chem. Soc. Rev., 2013,42, 5672-5683
Article type
Tutorial Review

Biomolecular hydration dynamics: a jump model perspective

A. C. Fogarty, E. Duboué-Dijon, F. Sterpone, J. T. Hynes and D. Laage, Chem. Soc. Rev., 2013, 42, 5672
DOI: 10.1039/C3CS60091B

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