Jump to main content
Jump to site search

Issue 17, 2013
Previous Article Next Article

To aggregate, or not to aggregate? considerations in the design and application of polymeric thermally-responsive nanoparticles

Author affiliations

Abstract

The aim of this review is to highlight some of the challenges in designing thermally responsive nanoparticles, where the responsivity is endowed by a responsive polymeric corona. A review of the literature reveals many contradictory observations upon heating these particles through their transition temperature. Indeed, both an increase in size due to aggregation and particle shrinkage have been reported for apparently similar materials. Furthermore, careful review of the literature shows that responsive nanoparticles do not have the same transition temperature or properties as their constituent polymers. These observations raise serious questions as to how to achieve the rational design of a responsive particle with a predictable and reproducible response. Here we highlight specific cases where conflicting results have been observed for spherical particles and put these results into the context of flat-surface grafted polymer brushes to explain the behaviour in terms of grafting density, curvature, chain end effects and the role of the underlying substrate. A better understanding of these observations should lead to the improved design of nanoparticles with real function and applications.

Graphical abstract: To aggregate, or not to aggregate? considerations in the design and application of polymeric thermally-responsive nanoparticles

Back to tab navigation

Publication details

The article was received on 30 Jan 2013 and first published on 09 Apr 2013


Article type: Review Article
DOI: 10.1039/C3CS60035A
Citation: Chem. Soc. Rev., 2013,42, 7204-7213
  • Open access: Creative Commons BY license
  •   Request permissions

    To aggregate, or not to aggregate? considerations in the design and application of polymeric thermally-responsive nanoparticles

    M. I. Gibson and R. K. O'Reilly, Chem. Soc. Rev., 2013, 42, 7204
    DOI: 10.1039/C3CS60035A

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements