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Issue 18, 2013
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Mechanochemical organic synthesis

Guan-Wu Wang*a  
Author affiliations

* Corresponding authors

a Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry, and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China
E-mail: gwang@ustc.edu.cn
Fax: +86 551 63607864
Tel: +86 551 63607864

Abstract

Recently, mechanical milling using a mixer mill or planetary mill has been fruitfully utilized in organic synthesis under solvent-free conditions. This review article provides a comprehensive overview of various solvent-free mechanochemical organic reactions, including metal-mediated or -catalyzed reactions, condensation reactions, nucleophilic additions, cascade reactions, Diels–Alder reactions, oxidations, reductions, halogenation/aminohalogenation, etc. The ball milling technique has also been applied to the synthesis of calixarenes, rotaxanes and cage compounds, asymmetric synthesis as well as the transformation of biologically active compounds.

Graphical abstract: Mechanochemical organic synthesis

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Publication details

The article was received on 24 Dec 2012 and first published on 09 May 2013


Article type: Review Article
DOI: 10.1039/C3CS35526H
Chem. Soc. Rev., 2013,42, 7668-7700

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    Mechanochemical organic synthesis

    G. Wang, Chem. Soc. Rev., 2013, 42, 7668
    DOI: 10.1039/C3CS35526H

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