Mechanochemical organic synthesis

Guan-Wu Wang

doi:10.1039/C3CS35526H

Mechanochemical organic synthesis

Guan-Wu Wang*^a

* Corresponding authors

^a Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry, and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China
E-mail: gwang@ustc.edu.cn
Fax: +86 551 63607864
Tel: +86 551 63607864

Abstract

Recently, mechanical milling using a mixer mill or planetary mill has been fruitfully utilized in organic synthesis under solvent-free conditions. This review article provides a comprehensive overview of various solvent-free mechanochemical organic reactions, including metal-mediated or -catalyzed reactions, condensation reactions, nucleophilic additions, cascade reactions, Diels–Alder reactions, oxidations, reductions, halogenation/aminohalogenation, etc. The ball milling technique has also been applied to the synthesis of calixarenes, rotaxanes and cage compounds, asymmetric synthesis as well as the transformation of biologically active compounds.

This article is part of the themed collection: Mechanochemistry

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Submitted

24 Dec 2012

First published

09 May 2013

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Chem. Soc. Rev., 2013,42, 7668-7700

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Review Article

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Mechanochemical organic synthesis

G. Wang, Chem. Soc. Rev., 2013, 42, 7668

DOI: 10.1039/C3CS35526H

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