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Issue 15, 2013
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Industrial use of immobilized enzymes

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Although many methods for enzyme immobilization have been described in patents and publications, relatively few processes employing immobilized enzymes have been successfully commercialized. The cost of most industrial enzymes is often only a minor component in overall process economics, and in these instances, the additional costs associated with enzyme immobilization are often not justified. More commonly the benefit realized from enzyme immobilization relates to the process advantages that an immobilized catalyst offers, for example, enabling continuous production, improved stability and the absence of the biocatalyst in the product stream. The development and attributes of several established and emerging industrial applications for immobilized enzymes, including high-fructose corn syrup production, pectin hydrolysis, debittering of fruit juices, interesterification of food fats and oils, biodiesel production, and carbon dioxide capture are reviewed herein, highlighting factors that define the advantages of enzyme immobilization.

Graphical abstract: Industrial use of immobilized enzymes

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Article information

10 Dec 2012
First published
25 Feb 2013

Chem. Soc. Rev., 2013,42, 6437-6474
Article type
Review Article

Industrial use of immobilized enzymes

R. DiCosimo, J. McAuliffe, A. J. Poulose and G. Bohlmann, Chem. Soc. Rev., 2013, 42, 6437
DOI: 10.1039/C3CS35506C

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