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Issue 10, 2013
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Chemical probing of glycans in cells and organisms

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Abstract

Among the four major building blocks of life, glycans play essential roles in numerous physiological and pathological processes. Due to their non-templated biosynthesis, advances towards elucidating the molecular details of glycan functions are relatively slow compared with the pace of protein and nucleic acid research. Over the past 30 years, chemical tools have emerged as powerful allies to genetics and molecular biology in the study of glycans in their native environment. This tutorial review will provide an overview of the recent technological developments in the field, as well as the progress in the application of these techniques to probe glycans in cells and organisms.

Graphical abstract: Chemical probing of glycans in cells and organisms

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Article information


Submitted
11 Oct 2012
First published
21 Dec 2012

Chem. Soc. Rev., 2013,42, 4284-4296
Article type
Tutorial Review

Chemical probing of glycans in cells and organisms

S. H. Rouhanifard, L. U. Nordstrøm, T. Zheng and P. Wu, Chem. Soc. Rev., 2013, 42, 4284
DOI: 10.1039/C2CS35416K

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