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Issue 10, 2013
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Chemical probing of glycans in cells and organisms

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Abstract

Among the four major building blocks of life, glycans play essential roles in numerous physiological and pathological processes. Due to their non-templated biosynthesis, advances towards elucidating the molecular details of glycan functions are relatively slow compared with the pace of protein and nucleic acid research. Over the past 30 years, chemical tools have emerged as powerful allies to genetics and molecular biology in the study of glycans in their native environment. This tutorial review will provide an overview of the recent technological developments in the field, as well as the progress in the application of these techniques to probe glycans in cells and organisms.

Graphical abstract: Chemical probing of glycans in cells and organisms

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Publication details

The article was received on 11 Oct 2012 and first published on 21 Dec 2012


Article type: Tutorial Review
DOI: 10.1039/C2CS35416K
Chem. Soc. Rev., 2013,42, 4284-4296

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    Chemical probing of glycans in cells and organisms

    S. H. Rouhanifard, L. U. Nordstrøm, T. Zheng and P. Wu, Chem. Soc. Rev., 2013, 42, 4284
    DOI: 10.1039/C2CS35416K

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