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Issue 10, 2013
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Carbohydrate microarrays

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Abstract

In the last decade, carbohydrate microarrays have been core technologies for analyzing carbohydrate-mediated recognition events in a high-throughput fashion. A number of methods have been exploited for immobilizing glycans on the solid surface in a microarray format. This microarray-based technology has been widely employed for rapid analysis of the glycan binding properties of lectins and antibodies, the quantitative measurements of glycan–protein interactions, detection of cells and pathogens, identification of disease-related anti-glycan antibodies for diagnosis, and fast assessment of substrate specificities of glycosyltransferases. This review covers the construction of carbohydrate microarrays, detection methods of carbohydrate microarrays and their applications in biological and biomedical research.

Graphical abstract: Carbohydrate microarrays

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Article information


Submitted
29 Sep 2012
First published
28 Nov 2012

Chem. Soc. Rev., 2013,42, 4310-4326
Article type
Review Article

Carbohydrate microarrays

S. Park, J. C. Gildersleeve, O. Blixt and I. Shin, Chem. Soc. Rev., 2013, 42, 4310
DOI: 10.1039/C2CS35401B

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