Issue 29, 2013

Ligand-free gadolinium oxide for in vivo T1-weighted magnetic resonance imaging

Abstract

Gadolinium oxide (Gd2O3), which can be used as a T1-weighted magnetic resonance imaging (MRI) contrast agent, has attracted intense attention in recent years. In this paper, ligand-free monoclinic Gd2O3 nanocrystals of 7.1 nm in diameter are synthesized by a simple and green approach, namely microsecond laser ablation of a gadolinium (Gd) target in deionized water. These nanocrystals obtain high r1 relaxivity of 5.53 s−1 mM−1, and their low toxicity was demonstrated by the cell viability of S18 cells and apoptosis in RAW264.7 cells. In vitro and in vivo MR images show these particles to be good T1-weighted MRI contrast agents. Base on the experimental results and theoretical analysis, we suggest that the purity of the Gd2O3 contributes to its high r1 relaxivity value, while the low toxicity is due to its good crystallinity. These findings show that laser ablation in liquid (LAL) is a promising strategy to synthesize ligand-free monoclinic Gd2O3 nanocrystals for use as high efficient T1-weighted MRI contrast agents.

Graphical abstract: Ligand-free gadolinium oxide for in vivo T1-weighted magnetic resonance imaging

Supplementary files

Article information

Article type
Paper
Submitted
10 Apr 2013
Accepted
10 May 2013
First published
17 May 2013

Phys. Chem. Chem. Phys., 2013,15, 12235-12240

Ligand-free gadolinium oxide for in vivo T1-weighted magnetic resonance imaging

N. Luo, X. Tian, C. Yang, J. Xiao, W. Hu, D. Chen and L. Li, Phys. Chem. Chem. Phys., 2013, 15, 12235 DOI: 10.1039/C3CP51530C

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