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Issue 10, 2013
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The effect of protein composition on hydration dynamics

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Abstract

Water dynamics at the surface of two homologous proteins with different thermal resistances is found to be unaffected by the different underlying amino-acid compositions, and when proteins are folded it responds similarly to temperature variations. Upon unfolding the water dynamics slowdown with respect to bulk decreases by a factor of two. Our findings are explained by the dominant topological perturbation induced by the protein on the water hydrogen bond dynamics.

Graphical abstract: The effect of protein composition on hydration dynamics

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Publication details

The article was received on 18 Dec 2012, accepted on 07 Jan 2013 and first published on 10 Jan 2013


Article type: Paper
DOI: 10.1039/C3CP44582H
Phys. Chem. Chem. Phys., 2013,15, 3570-3576

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    The effect of protein composition on hydration dynamics

    O. Rahaman, S. Melchionna, D. Laage and F. Sterpone, Phys. Chem. Chem. Phys., 2013, 15, 3570
    DOI: 10.1039/C3CP44582H

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