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Issue 12, 2013
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Photothermal signal distribution analysis (PhoSDA)

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Photothermal correlation spectroscopy (PhoCS) is a powerful counterpart to fluorescence correlation spectroscopy (FCS). Using PhoCS it is possible to probe the dynamics of non-fluorescent and non-bleaching ultra-stable metal-nanoparticles in solution and biological specimen, where they can be used as tracers and markers. This paper complements the absorption correlation method by a histogram analysis framework, the photothermal signal distribution analysis (PhoSDA). It is hereby possible to extract individual absorbent tracer concentrations, size dispersions, heterogeneous populations and focal geometry parameters which are otherwise inaccessible by correlation analysis.

Graphical abstract: Photothermal signal distribution analysis (PhoSDA)

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Article information

17 Nov 2012
18 Jan 2013
First published
18 Jan 2013

Phys. Chem. Chem. Phys., 2013,15, 4250-4257
Article type

Photothermal signal distribution analysis (PhoSDA)

M. Selmke, M. Braun, R. Schachoff and F. Cichos, Phys. Chem. Chem. Phys., 2013, 15, 4250
DOI: 10.1039/C3CP44092C

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