Issue 6, 2014
From the journal:

Chemical Communications

Acyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones†

Ahmed R. Akhbar,a   Vijay Chudasama,*a   Richard J. Fitzmaurice,a   Lyn Powellb  and  Stephen Caddick*a  

* Corresponding authors

a Department of Chemistry, University College London, London, UK
E-mail: VPEnterprise@ucl.ac.uk, v.chudasama@ucl.ac.uk
Tel: +44 (0)20 3108 5071

b AstraZeneca, Charter Way, Silk Road Business Park, Macclesfield, Cheshire, UK

Abstract

In this communication we describe a novel strategy for the formation of valuable diaryl and aryl alkyl ketones from acyl hydrazides. A wide variety of ketones are prepared and the mild reaction conditions allow for the use of a range of functionalities, especially in the synthesis of diaryl ketones.

Graphical abstract: Acyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones

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Article information

DOI
https://doi.org/10.1039/C3CC47967F
Article type
Communication
Submitted
16 Oct 2013
Accepted
22 Nov 2013
First published
22 Nov 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 743-746

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Acyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones

A. R. Akhbar, V. Chudasama, R. J. Fitzmaurice, L. Powell and S. Caddick, Chem. Commun., 2014, 50, 743 DOI: 10.1039/C3CC47967F

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