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Issue 40, 2014
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Targeting cancer cells with folic acid–iminoboronate fluorescent conjugates

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Abstract

Herein we present the synthesis of fluorescent 2-acetylbenzeneboronic acids that undergo B–N promoted conjugation with lysozyme and N-(2-aminoethyl) folic acid (EDA-FA), generating conjugates that are selectively recognized and internalized by cancer cells that over-express folic acid receptors.

Graphical abstract: Targeting cancer cells with folic acid–iminoboronate fluorescent conjugates

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Supplementary files

Article information


Submitted
01 Oct 2013
Accepted
04 Nov 2013
First published
05 Nov 2013

This article is Open Access

Chem. Commun., 2014,50, 5261-5263
Article type
Communication

Targeting cancer cells with folic acid–iminoboronate fluorescent conjugates

P. M. S. D. Cal, R. F. M. Frade, V. Chudasama, C. Cordeiro, S. Caddick and P. M. P. Gois, Chem. Commun., 2014, 50, 5261
DOI: 10.1039/C3CC47534D

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