Issue 89, 2013
From the journal:

Chemical Communications

A two-directional approach to pyrrolizidines: total syntheses and biological evaluation of alkaloid cis-223B and (±)-xenovenine†

Alexandre Barthelme,*a   David Richards,b   Ian R. Mellorb  and  Robert A. Stockman*a  

* Corresponding authors

a School of Chemistry, University of Nottingham, Nottingham, UK
E-mail: Robert.stockman@nottingham.ac.uk

b School of Biology, University of Nottingham, Nottingham, UK

Abstract

Total syntheses of alkaloid cis-223B and xenovenine are reported in 3 and 4 steps respectively using a two-directional synthesis/triple reductive amination strategy, and their neurotoxic properties assessed.

Graphical abstract: A two-directional approach to pyrrolizidines: total syntheses and biological evaluation of alkaloid cis-223B and (±)-xenovenine

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Article information

DOI
https://doi.org/10.1039/C3CC46800C
Article type
Communication
Submitted
05 Sep 2013
Accepted
27 Sep 2013
First published
27 Sep 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2013,49, 10507-10509

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A two-directional approach to pyrrolizidines: total syntheses and biological evaluation of alkaloid cis-223B and (±)-xenovenine

A. Barthelme, D. Richards, I. R. Mellor and R. A. Stockman, Chem. Commun., 2013, 49, 10507 DOI: 10.1039/C3CC46800C

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