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Issue 95, 2013
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Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic core

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Abstract

The amyloidogenic core in the TAR DNA-binding protein (TDP-43) C-terminal fragment has been characterized with its chemical, biochemical, and structural properties delineated. Various properties of the core sequence, including membrane impairment ability and the seeding effect, have also been studied.

Graphical abstract: Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic core

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Publication details

The article was received on 04 Sep 2013, accepted on 08 Oct 2013 and first published on 08 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC46762G
Chem. Commun., 2013,49, 11212-11214

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    Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic core

    G. C. Liu, B. P. Chen, N. T. Ye, C. Wang, W. Chen, H. Lee, S. I. Chan and J. J. Huang, Chem. Commun., 2013, 49, 11212
    DOI: 10.1039/C3CC46762G

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