Issue 95, 2013
From the journal:

Chemical Communications

Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic core†

Gerard Chun-Hao Liu,ab   Bryan Po-Wen Chen,c   Nancy Ting-Juan Ye,d   Chih-Hsien Wang,e   Wenlung Chen,e   Hsien-Ming Lee,a   Sunney I. Chanab  and  Joseph Jen-Tse Huang*a  

* Corresponding authors

a Institute of Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan
E-mail: jthuang@chem.sinica.edu.tw
Fax: +886-2-27831237
Tel: +886-2-27898652

b Department of Chemistry, National Taiwan University, Taipei 106, Taiwan

c Department of Chemistry, Tamkang University, Taipei 251, Taiwan

d Department of Applied Physics and Chemistry, University of Taipei, Taipei 100, Taiwan

e Department of Applied Chemistry, National Chiayi University, Chiayi 600, Taiwan

Abstract

The amyloidogenic core in the TAR DNA-binding protein (TDP-43) C-terminal fragment has been characterized with its chemical, biochemical, and structural properties delineated. Various properties of the core sequence, including membrane impairment ability and the seeding effect, have also been studied.

Graphical abstract: Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic core

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Article information

DOI
https://doi.org/10.1039/C3CC46762G
Article type
Communication
Submitted
04 Sep 2013
Accepted
08 Oct 2013
First published
08 Oct 2013

Chem. Commun., 2013,49, 11212-11214

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Delineating the membrane-disrupting and seeding properties of the TDP-43 amyloidogenic core

G. C. Liu, B. P. Chen, N. T. Ye, C. Wang, W. Chen, H. Lee, S. I. Chan and J. J. Huang, Chem. Commun., 2013, 49, 11212 DOI: 10.1039/C3CC46762G

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