Issue 96, 2013
From the journal:

Chemical Communications

An NBD-armed tetraaza macrocyclic lysosomal-targeted fluorescent probe for imaging copper(ii) ions†

Xiaobo Wang,a   Xiaoyan Ma,a   Zhen Yang,a   Zhong Zhang,b   Jinghan Wen,a   Zhirong Geng*a  and  Zhilin Wang*a  

* Corresponding authors

a State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China
E-mail: wangzl@nju.edu.cn, gengzr@nju.edu.cn

b College of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin 541004, P. R. China

Abstract

An NBD-armed tetraaza macrocyclic lysosomal-targeted fluorescent probe for detecting Cu2+ was synthesized and used for fluorescence imaging in HeLa cells. The probe was specifically localized in lysosomes and successfully applied to visualize Cu2+ as well as to monitor Cu2+ level changes in the lysosomes of living cells.

Graphical abstract: An NBD-armed tetraaza macrocyclic lysosomal-targeted fluorescent probe for imaging copper(ii) ions

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Article information

DOI
https://doi.org/10.1039/C3CC46585C
Article type
Communication
Submitted
28 Aug 2013
Accepted
08 Oct 2013
First published
08 Oct 2013

Chem. Commun., 2013,49, 11263-11265

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An NBD-armed tetraaza macrocyclic lysosomal-targeted fluorescent probe for imaging copper(II) ions

X. Wang, X. Ma, Z. Yang, Z. Zhang, J. Wen, Z. Geng and Z. Wang, Chem. Commun., 2013, 49, 11263 DOI: 10.1039/C3CC46585C

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