Issue 85, 2013
From the journal:

Chemical Communications

2,4-Diamino-6,7-dimethylpteridine as a fluorescent ligand for binding and sensing an orphan cytosine in RNA duplexes†

Yusuke Sato,a   Yu Toriyabe,a   Seiichi Nishizawaa  and  Norio Teramae*a  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan
E-mail: teramae@m.tohoku.ac.jp
Fax: +81-22-795-6552
Tel: +81-22-795-6552

Abstract

We report on a new fluorescent ligand, 2,4-diamino-6,7-dimethylpteridine, that can strongly and selectively bind to an orphan cytosine opposite an abasic site in RNA duplexes. We describe a significant effect of the substituents attached to the pteridine ring on the binding behavior in comparison with a structurally-similar pteridine derivative.

Graphical abstract: 2,4-Diamino-6,7-dimethylpteridine as a fluorescent ligand for binding and sensing an orphan cytosine in RNA duplexes

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Article information

DOI
https://doi.org/10.1039/C3CC46085A
Article type
Communication
Submitted
09 Aug 2013
Accepted
05 Sep 2013
First published
05 Sep 2013

Chem. Commun., 2013,49, 9983-9985

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2,4-Diamino-6,7-dimethylpteridine as a fluorescent ligand for binding and sensing an orphan cytosine in RNA duplexes

Y. Sato, Y. Toriyabe, S. Nishizawa and N. Teramae, Chem. Commun., 2013, 49, 9983 DOI: 10.1039/C3CC46085A

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