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Issue 85, 2013
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Trichloromethyl ketones: asymmetric transfer hydrogenation and subsequent Jocic-type reactions with amines

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Abstract

Amino-amides are important pharmaceutical building-blocks. The enantioselective reduction of trichloromethyl ketones using ruthenium transfer hydrogenation catalysts is reported. The products react in a range of Jocic-type reactions to give enantiomerically enriched amino-amides.

Graphical abstract: Trichloromethyl ketones: asymmetric transfer hydrogenation and subsequent Jocic-type reactions with amines

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Article information


Submitted
08 Aug 2013
Accepted
13 Sep 2013
First published
16 Sep 2013

Chem. Commun., 2013,49, 10022-10024
Article type
Communication

Trichloromethyl ketones: asymmetric transfer hydrogenation and subsequent Jocic-type reactions with amines

M. S. Perryman, M. E. Harris, J. L. Foster, A. Joshi, G. J. Clarkson and D. J. Fox, Chem. Commun., 2013, 49, 10022
DOI: 10.1039/C3CC46070C

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