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Issue 87, 2013
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Asymmetric domino synthesis of indanes bearing four contiguous stereocentres catalyzed by sub-mol% loadings of a squaramide in minutes

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Abstract

An efficient diastereo- and enantioselective synthesis of polyfunctionalized indanes bearing four contiguous stereogenic centres in generally very short reaction times and sub-mol% squaramide catalyst loadings has been developed. The novel methodology creates a maximum of two stereocentres per bond formation via an organocatalytic Michael–Henry domino reaction.

Graphical abstract: Asymmetric domino synthesis of indanes bearing four contiguous stereocentres catalyzed by sub-mol% loadings of a squaramide in minutes

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Article information


Submitted
07 Aug 2013
Accepted
09 Sep 2013
First published
10 Sep 2013

Chem. Commun., 2013,49, 10230-10232
Article type
Communication

Asymmetric domino synthesis of indanes bearing four contiguous stereocentres catalyzed by sub-mol% loadings of a squaramide in minutes

C. C. J. Loh, D. Hack and D. Enders, Chem. Commun., 2013, 49, 10230
DOI: 10.1039/C3CC46033A

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