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Issue 80, 2013
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Direct and selective tagging of cysteine residues in peptides and proteins with 4-nitropyridyl lanthanide complexes

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Abstract

A cysteine-selective tagging method in water is reported, based on rapid displacement of a pyridyl nitro-substituent in simple pyridines and lanthanide complexes. The conjugation reaction creates a short link between the tag and peptide, holding the peptide closer to the Ln3+ ion and with reduced flexibility compared to existing methods.

Graphical abstract: Direct and selective tagging of cysteine residues in peptides and proteins with 4-nitropyridyl lanthanide complexes

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Publication details

The article was received on 01 Aug 2013, accepted on 21 Aug 2013 and first published on 21 Aug 2013


Article type: Communication
DOI: 10.1039/C3CC45875J
Citation: Chem. Commun., 2013,49, 9104-9106

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    Direct and selective tagging of cysteine residues in peptides and proteins with 4-nitropyridyl lanthanide complexes

    K. L. Gempf, S. J. Butler, A. M. Funk and D. Parker, Chem. Commun., 2013, 49, 9104
    DOI: 10.1039/C3CC45875J

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