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Issue 92, 2013
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Expanding the scope of oxime ligation: facile synthesis of large cyclopeptide-based glycodendrimers

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Abstract

A new series of 64-valent glycodendrimers was prepared in excellent yield and purity using a divergent and iterative strategy based on oxime ligation. Enzyme-linked lectin assays revealed the first nanomolar inhibitor for the fucose-specific lectin isolated from Ulex europaeus.

Graphical abstract: Expanding the scope of oxime ligation: facile synthesis of large cyclopeptide-based glycodendrimers

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Article information


Submitted
16 Jul 2013
Accepted
29 Sep 2013
First published
30 Sep 2013

Chem. Commun., 2013,49, 10796-10798
Article type
Communication

Expanding the scope of oxime ligation: facile synthesis of large cyclopeptide-based glycodendrimers

B. Thomas, N. Berthet, J. Garcia, P. Dumy and O. Renaudet, Chem. Commun., 2013, 49, 10796
DOI: 10.1039/C3CC45368E

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