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Issue 78, 2013
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Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

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Abstract

We have combined the benefits of both microfluidics and flow hydrogenation to provide facile access to previously underutilized reduction and protecting group chemistries for PET imaging applications. The rapid removal of an O-benzyl protecting group to prepare 2-[18F]fluoroquinolin-8-ol and the reduction of a nitro group in the synthesis of 4-[18F]fluoroaniline were achieved within 3 minutes.

Graphical abstract: Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

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Article information


Submitted
09 Jul 2013
Accepted
25 Jul 2013
First published
29 Jul 2013

Chem. Commun., 2013,49, 8755-8757
Article type
Communication

Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

S. H. Liang, T. L. Collier, B. H. Rotstein, R. Lewis, M. Steck and N. Vasdev, Chem. Commun., 2013, 49, 8755
DOI: 10.1039/C3CC45166F

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