Issue 93, 2013
From the journal:

Chemical Communications

Allosteric inhibitors of HMG-CoA reductase, the key enzyme involved in cholesterol biosynthesis†

Adi Haber,a   Amona Abu-Younis Ali,a   Michael Aviramb  and  Zeev Gross*a  

* Corresponding authors

a Schulich Faculty of Chemistry, Technion – Israel Institute of Technology, Technion City, Haifa 32000, Israel
E-mail: chr10zg@tx.technion.ac.il

b Lipid Research Laboratory, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Rambam Medical Center, Haifa 31096, Israel

Abstract

The corrole-based catalytic antioxidant 1-Fe reduced the cholesterol biosynthesis ability of macrophages, harvested from mice treated with it. 1-Fe and a non-redox active analogue of it affect the committed step of the biosynthetic pathway – the HMG-CoA reductase catalysed reaction – by acting as allosteric inhibitors of this key enzyme.

Graphical abstract: Allosteric inhibitors of HMG-CoA reductase, the key enzyme involved in cholesterol biosynthesis

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Article information

DOI
https://doi.org/10.1039/C3CC44740E
Article type
Communication
Submitted
24 Jun 2013
Accepted
25 Jul 2013
First published
26 Jul 2013

Chem. Commun., 2013,49, 10917-10919

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Allosteric inhibitors of HMG-CoA reductase, the key enzyme involved in cholesterol biosynthesis

A. Haber, A. Abu-Younis Ali, M. Aviram and Z. Gross, Chem. Commun., 2013, 49, 10917 DOI: 10.1039/C3CC44740E

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