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Issue 80, 2013
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Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors

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Abstract

We describe coumarin derivatives that are non-fluorescent in aqueous buffers and that very selectively bind to transthyretin (TTR) in complex biological environments potently inhibiting TTR amyloidogenesis while also exhibiting sensitive off–on fluorescent sensing of the properly folded quaternary structure of TTR.

Graphical abstract: Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors

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Supplementary files

Article information


Submitted
21 Jun 2013
Accepted
06 Aug 2013
First published
07 Aug 2013

Chem. Commun., 2013,49, 9188-9190
Article type
Communication

Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors

N. Myung, S. Connelly, B. Kim, S. J. Park, I. A. Wilson, J. W. Kelly and S. Choi, Chem. Commun., 2013, 49, 9188
DOI: 10.1039/C3CC44667K

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