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Issue 68, 2013
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Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine

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Abstract

A key intermediate, difluoromethylene phosphobetaine, in the Wittig reaction of ClCF2CO2Na–Ph3P with aldehydes was synthesized and characterized, which confirmed the reaction mechanism. The decarboxylation of this stable intermediate was a convenient approach for Wittig difluroolefination. Its reactivity could be adjusted by the modification of the substituent on the phosphorus.

Graphical abstract: Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine

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Article information


Submitted
06 Jun 2013
Accepted
26 Jun 2013
First published
27 Jun 2013

Chem. Commun., 2013,49, 7513-7515
Article type
Communication

Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine

J. Zheng, J. Cai, J. Lin, Y. Guo and J. Xiao, Chem. Commun., 2013, 49, 7513
DOI: 10.1039/C3CC44271C

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