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Issue 84, 2013
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Environmentally responsive MRI contrast agents

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Abstract

Biomedical imaging techniques can provide a vast amount of anatomical information, enabling diagnosis and the monitoring of disease and treatment profile. MRI uniquely offers convenient, non-invasive, high resolution tomographic imaging. A considerable amount of effort has been invested, across several decades, in the design of non toxic paramagnetic contrast agents capable of enhancing positive MRI signal contrast. Recently, focus has shifted towards the development of agents capable of specifically reporting on their local biochemical environment, where a switch in image contrast is triggered by a specific stimulus/biochemical variable. Such an ability would not only strengthen diagnosis but also provide unique disease-specific biochemical insight. This feature article focuses on recent progress in the development of MRI contrast switching with molecular, macromolecular and nanoparticle-based agents.

Graphical abstract: Environmentally responsive MRI contrast agents

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Publication details

The article was received on 06 Jun 2013, accepted on 09 Sep 2013 and first published on 10 Sep 2013


Article type: Feature Article
DOI: 10.1039/C3CC44268C
Citation: Chem. Commun., 2013,49, 9704-9721
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    Environmentally responsive MRI contrast agents

    G. Davies, I. Kramberger and J. J. Davis, Chem. Commun., 2013, 49, 9704
    DOI: 10.1039/C3CC44268C

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