Metal-free oxidative hydroxyalkylarylation of activated alkenes by direct sp3 C–H functionalization of alcohols

Yuan Meng; Li-Na Guo; Hua Wang; Xin-Hua Duan

doi:10.1039/C3CC44055A

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Metal-free oxidative hydroxyalkylarylation of activated alkenes by direct sp³ C–H functionalization of alcohols†

Yuan Meng,^a Li-Na Guo,*^a Hua Wang^a and Xin-Hua Duan*^a

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* Corresponding authors

^a Department of Chemistry, School of Science and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an 710049, China
E-mail: guoln81@mail.xjtu.edu.cn, duanxh@mail.xjtu.edu.cn

Abstract

A metal-free tandem radical addition/cyclization reaction of activated alkenes and alcohols has been developed. The process provides an efficient and atom economical access to various valuable hydroxyl-containing oxindoles through the direct sp³ C–H functionalization of alcohols.

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Article information

DOI: https://doi.org/10.1039/C3CC44055A
Article type: Communication
Submitted: 30 May 2013
Accepted: 27 Jun 2013
First published: 28 Jun 2013

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Chem. Commun., 2013,49, 7540-7542

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Metal-free oxidative hydroxyalkylarylation of activated alkenes by direct sp³ C–H functionalization of alcohols

Y. Meng, L. Guo, H. Wang and X. Duan, Chem. Commun., 2013, 49, 7540 DOI: 10.1039/C3CC44055A

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Chemical Communications