PHIP-label: parahydrogen-induced polarization in propargylglycine-containing synthetic oligopeptides

Marco Körner; Grit Sauer; Andreas Heil; Daichi Nasu; Martin Empting; Daniel Tietze; Stephan Voigt; Heiko Weidler; Torsten Gutmann; Olga Avrutina; Harald Kolmar; Tomasz Ratajczyk; Gerd Buntkowsky

doi:10.1039/C3CC43978J

PHIP-label: parahydrogen-induced polarization in propargylglycine-containing synthetic oligopeptides†

Marco Körner,‡^a Grit Sauer,‡^a Andreas Heil,^a Daichi Nasu,^b Martin Empting,^b Daniel Tietze,^a Stephan Voigt,^a Heiko Weidler,^a Torsten Gutmann,^a Olga Avrutina,^b Harald Kolmar,^b Tomasz Ratajczyk*^ac and Gerd Buntkowsky*^a

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* Corresponding authors

^a TU Darmstadt, Eduard-Zintl-Institut für Anorganische und Physikalische Chemie, Petersenstr. 20, Darmstadt, Germany
E-mail: Gerd.Buntkowsky@chemie.tu-darmstadt.de, tratajczyk@ichf.edu.pl

^b TU Darmstadt, Clemens-Schöpf-Institut für Organische Chemie und Biochemie, Petersenstr. 22, Darmstadt, Germany

^c Polish Academy of Sciences, Institute of Physical Chemistry, Kasprzaka 44/52, 01-224 Warszawa, Poland

Abstract

The unsaturated side chain of L-propargylglycine (Pra) was used to study parahydrogen-induced polarization (PHIP) in synthetic oligopeptides. For the first time PHIP-induced NMR signal enhancement was demonstrated using model peptides bearing various functional side chains.

Chemical Communications

PHIP-label: parahydrogen-induced polarization in propargylglycine-containing synthetic oligopeptides†

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PHIP-label: parahydrogen-induced polarization in propargylglycine-containing synthetic oligopeptides

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