Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 68, 2013
Previous Article Next Article

Lewis acid-catalyzed regioselective synthesis of chiral α-fluoroalkyl amines via asymmetric addition of silyl dienolates to fluorinated sulfinylimines

Author affiliations

Abstract

A tunable and highly regio- and diastereoselective addition of acyclic silyl dienolates 2 to several α-fluoroalkyl sulfinylimines 1 was developed. By appropriate choice of the Lewis acid catalyst, two new chiral α-fluoroalkyl amines 3 and 4 were obtained in good yields and excellent diastereoselectivities (up to >99 : 1 dr), respectively.

Graphical abstract: Lewis acid-catalyzed regioselective synthesis of chiral α-fluoroalkyl amines via asymmetric addition of silyl dienolates to fluorinated sulfinylimines

Back to tab navigation

Supplementary files

Publication details

The article was received on 18 May 2013, accepted on 20 Jun 2013 and first published on 21 Jun 2013


Article type: Communication
DOI: 10.1039/C3CC43741H
Citation: Chem. Commun., 2013,49, 7492-7494

  •   Request permissions

    Lewis acid-catalyzed regioselective synthesis of chiral α-fluoroalkyl amines via asymmetric addition of silyl dienolates to fluorinated sulfinylimines

    Y. Liu, J. Liu, Y. Huang and F. Qing, Chem. Commun., 2013, 49, 7492
    DOI: 10.1039/C3CC43741H

Search articles by author

Spotlight

Advertisements