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Issue 67, 2013
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Desymmetrization of 4,6-diprotected myo-inositol

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The asymmetric desymmetrization of 4,6-diprotected myo-inositol derivatives was achieved by using a bifunctional, readily available nucleophilic catalyst. The orthogonally protected products were obtained in 80–99% yield with 90–99% ee. Such structures serve as potential enantiopure building blocks for the synthesis of myo-inositol phosphates.

Graphical abstract: Desymmetrization of 4,6-diprotected myo-inositol

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The article was received on 15 May 2013, accepted on 26 Jun 2013 and first published on 27 Jun 2013

Article type: Communication
DOI: 10.1039/C3CC43663B
Citation: Chem. Commun., 2013,49, 7409-7411
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    Desymmetrization of 4,6-diprotected myo-inositol

    M. B. Lauber, C. Daniliuc and J. Paradies, Chem. Commun., 2013, 49, 7409
    DOI: 10.1039/C3CC43663B

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