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Issue 74, 2013
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Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells

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Abstract

The multifunctional DNAzyme (Dz) delivery system is developed based on nano-sized graphene oxide (nGO) for simultaneous detection and knockdown of the target gene. The Dz/nGO complex system allowed convenient monitoring of HCV mRNA in living cells and silencing of the HCV gene expression by Dz-mediated catalytic cleavage concurrently.

Graphical abstract: Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells

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Article information


Submitted
07 May 2013
Accepted
17 Jul 2013
First published
17 Jul 2013

Chem. Commun., 2013,49, 8241-8243
Article type
Communication

Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells

S. Kim, S. Ryoo, H. Na, Y. Kim, B. Choi, Y. Lee, D. Kim and D. Min, Chem. Commun., 2013, 49, 8241
DOI: 10.1039/C3CC43368D

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