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Issue 53, 2013
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Catalytic asymmetric conjugate addition of Grignard reagents to chromones

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Abstract

A highly regio- and enantioselective copper catalysed direct conjugate addition of Grignard reagents to chromones has been developed taking advantage of the reduced reactivity of the resulting magnesium enolates. This methodology tolerates a broad scope of alkyl Grignards including secondary alkyl magnesium reagents as well as functionalised chromones.

Graphical abstract: Catalytic asymmetric conjugate addition of Grignard reagents to chromones

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Article information


Submitted
26 Apr 2013
Accepted
16 May 2013
First published
16 May 2013

Chem. Commun., 2013,49, 5933-5935
Article type
Communication

Catalytic asymmetric conjugate addition of Grignard reagents to chromones

C. Vila, V. Hornillos, M. Fañanás-Mastral and B. L. Feringa, Chem. Commun., 2013, 49, 5933
DOI: 10.1039/C3CC43105C

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