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Issue 69, 2013
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Electric field induced DNA damage: an open door for selective mutations

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Abstract

Intense electric fields activate the mutagenic mechanism of a single guanine–cytosine base pair. Would they be able to induce a permanent mutation in real DNA? This question is addressed here by modeling a DNA-embedded fragment with state-of-the-art theoretical tools. We show how DNA can, in principle, be mutated if an appropriate electric field is applied.

Graphical abstract: Electric field induced DNA damage: an open door for selective mutations

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Supplementary files

Article information


Submitted
09 Apr 2013
Accepted
13 May 2013
First published
14 May 2013

Chem. Commun., 2013,49, 7578-7580
Article type
Communication

Electric field induced DNA damage: an open door for selective mutations

J. P. Cerón-Carrasco and D. Jacquemin, Chem. Commun., 2013, 49, 7578
DOI: 10.1039/C3CC42593B

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