Issue 55, 2013
From the journal:

Chemical Communications

Functional dissection and module swapping of fungal cyclooligomer depsipeptide synthetases†

Dayu Yu,‡ab   Fuchao Xu,‡ab   David Gageb  and  Jixun Zhan*b  

* Corresponding authors

a Department of Applied Chemistry and Biological Engineering, College of Chemical Engineering, Northeast Dianli University, Jilin, Jilin 132012, China

b Department of Biological Engineering, Utah State University, 4105 Old Main Hill, Logan, UT 84322, USA
E-mail: jixun.zhan@usu.edu
Fax: +1 435 797 1248
Tel: +1 435 797 8774

Abstract

BbBSLS and BbBEAS were dissected and reconstituted in Saccharomyces cerevisiae. The intermodular linker is essential for the reconstitution of the separate modules. Module 1 can be swapped between BbBEAS and BbBSLS, while modules 2 and 3 control the product profiles. BbBSLS is a flexible enzyme that also synthesizes beauvericins.

Graphical abstract: Functional dissection and module swapping of fungal cyclooligomer depsipeptide synthetases

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC42425A
Article type
Communication
Submitted
03 Apr 2013
Accepted
16 May 2013
First published
17 May 2013

Chem. Commun., 2013,49, 6176-6178

Permissions

Request permissions

Functional dissection and module swapping of fungal cyclooligomer depsipeptide synthetases

D. Yu, F. Xu, D. Gage and J. Zhan, Chem. Commun., 2013, 49, 6176 DOI: 10.1039/C3CC42425A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements