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Issue 45, 2013
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Reversible chemoselective tagging and functionalization of methionine containing peptides

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Abstract

Reagents were developed to allow chemoselective tagging of methionine residues in peptides and polypeptides, subsequent bioorthogonal functionalization of the tags, and cleavage of the tags when desired. This methodology can be used for triggered release of therapeutic peptides, or release of tagged protein digests from affinity columns.

Graphical abstract: Reversible chemoselective tagging and functionalization of methionine containing peptides

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Supplementary files

Article information


Submitted
26 Mar 2013
Accepted
19 Apr 2013
First published
23 Apr 2013

Chem. Commun., 2013,49, 5144-5146
Article type
Communication

Reversible chemoselective tagging and functionalization of methionine containing peptides

J. R. Kramer and T. J. Deming, Chem. Commun., 2013, 49, 5144 DOI: 10.1039/C3CC42214C

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