Shinji Kitagaki, Takahiro Ueda and Chisato Mukai
Chem. Commun., 2013,49, 4030-4032
DOI:
10.1039/C3CC41789A,
Communication
A bis(thiourea) organocatalyst with a planar chiral [2.2]paracyclophane backbone has been synthesized and applied to the Henry reaction. The obtained high reactivity and enantioselectivity from the reaction of aromatic aldehydes with nitroalkanes suggested the significant potential of [2.2]paracyclophane to serve as the backbone of the organocatalyst.
![Graphical abstract: Planar chiral [2.2]paracyclophane-based bis(thiourea) catalyst: application to asymmetric Henry reaction](/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C3CC41789A "Graphical abstract")
