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Issue 45, 2013

Nona-copper(ii)-containing 18-tungsto-8-arsenate(iii) exhibits antitumor activity

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Abstract

The nona-CuII-containing tungstoarsenate(III) [H4{CuII9AsIII6O15(H2O)6}(α-AsIIIW9O33)2]8− (1a) has been synthesized and characterized. Polyanion 1a comprises a unique, cylindrical {CuII9AsIII6O15(H2O)6}6+ cluster, which forms a large central cavity and is capped on either end by an [α-AsIIIW9O33]9− capping group. It exhibits remarkable activity against K562 leukaemia cells, as well as induces HepG2 cell apoptosis and autophagy.

Graphical abstract: Nona-copper(ii)-containing 18-tungsto-8-arsenate(iii) exhibits antitumor activity

Supplementary files

Article information


Submitted
04 Mar 2013
Accepted
18 Apr 2013
First published
18 Apr 2013

Chem. Commun., 2013,49, 5189-5191
Article type
Communication

Nona-copper(II)-containing 18-tungsto-8-arsenate(III) exhibits antitumor activity

Z. Zhou, D. Zhang, L. Yang, P. Ma, Y. Si, U. Kortz, J. Niu and J. Wang, Chem. Commun., 2013, 49, 5189 DOI: 10.1039/C3CC41628C

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