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A novel surface-enhanced Raman scattering (SERS) method is demonstrated to detect L-histidine based on DNAzyme which can specifically recognize L-histidine. Through a target recycling cascade amplification strategy, the DNAzyme-based SERS sensing system affords very high sensitivity for L-histidine with a detection limit of 0.56 nM.

Graphical abstract: A sensitive SERS assay of l-histidine via a DNAzyme-activated target recycling cascade amplification strategy

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