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Issue 42, 2013
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A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide

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Abstract

A small molecule, protein mimetic based approach is shown to specifically inhibit lipid catalysed self-assembly of islet amyloid polypeptide (IAPP). The lipid-bound oligomerization of this peptide is implicated in cellular dysfunction of insulin secreting β-cells in type II diabetes.

Graphical abstract: A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide

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Publication details

The article was received on 25 Feb 2013, accepted on 03 Apr 2013 and first published on 04 Apr 2013


Article type: Communication
DOI: 10.1039/C3CC41452C
Citation: Chem. Commun., 2013,49, 4749-4751

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    A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide

    S. Kumar and A. D. Miranker, Chem. Commun., 2013, 49, 4749
    DOI: 10.1039/C3CC41452C

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