Issue 40, 2013
From the journal:

Chemical Communications

Anti-Bredt N-heterocyclic carbene: an efficient ligand for the gold(i)-catalyzed hydroamination of terminal alkynes with parent hydrazine†

María J. López-Gómez,a   David Martina  and  Guy Bertrand*a  

* Corresponding authors

a UCSD-CNRS Joint Research Laboratory (UMI 3555), Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0343, USA
E-mail: guybertrand@ucsd.edu
Tel: +1 858 534 5412

Abstract

An anti-Bredt N-heterocyclic carbene gold(I) chloride complex was synthesized by taking advantage of the reversible insertion of the free carbene into the NH bond of hexamethyldisilazane. This precatalyst promotes the parent hydrazine hydroamination of terminal alkynes at room temperature.

Graphical abstract: Anti-Bredt N-heterocyclic carbene: an efficient ligand for the gold(i)-catalyzed hydroamination of terminal alkynes with parent hydrazine

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Article information

DOI
https://doi.org/10.1039/C3CC41279B
Article type
Communication
Submitted
19 Feb 2013
Accepted
22 Mar 2013
First published
26 Mar 2013

Chem. Commun., 2013,49, 4483-4485

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Anti-Bredt N-heterocyclic carbene: an efficient ligand for the gold(I)-catalyzed hydroamination of terminal alkynes with parent hydrazine

M. J. López-Gómez, D. Martin and G. Bertrand, Chem. Commun., 2013, 49, 4483 DOI: 10.1039/C3CC41279B

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