Issue 44, 2013
From the journal:

Chemical Communications

Synthesis of substituted hydantoins in low melting mixtures†

Sangram Gore,ab   Kiran Chinthapally,a   Sundarababu Baskaran*a  and  Burkhard König*b  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India
E-mail: sbhaskar@iitm.ac.in
Fax: +91-44-2257-0545
Tel: +91-44-2257-4218

b Institut für Organische Chemie, Universität Regensburg, Regensburg, Germany
E-mail: burkhard.koenig@chemi.uniregensburg.de
Fax: +49-941-9431717
Tel: +49-941-9434576

Abstract

A novel domino synthesis of 1,3,5-trisubstituted hydantoin derivatives has been developed in low melting L-(+)-tartaric acid–DMU melt mixtures. The functionalized hydantoins are obtained in good yields from β,γ-unsaturated ketoacids and urea under environmentally benign and simple reaction conditions.

Graphical abstract: Synthesis of substituted hydantoins in low melting mixtures

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Article information

DOI
https://doi.org/10.1039/C3CC41254G
Article type
Communication
Submitted
17 Feb 2013
Accepted
17 Apr 2013
First published
17 Apr 2013

Chem. Commun., 2013,49, 5052-5054

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Synthesis of substituted hydantoins in low melting mixtures

S. Gore, K. Chinthapally, S. Baskaran and B. König, Chem. Commun., 2013, 49, 5052 DOI: 10.1039/C3CC41254G

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