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Issue 52, 2013
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Diverse topologies in dynamic combinatorial libraries from tri- and mono-thiols in water: sensitivity to weak supramolecular interactions

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Abstract

We describe here the use of disulfide exchange reactions to generate distinct supramolecular topologies within a dynamic combinatorial library (DCL) derived from tri- and mono-functionalised thiol components in water. This approach allows for the effective expansion of structural diversity within a DCL, and also provides a sensitive probe for weak supramolecular interactions.

Graphical abstract: Diverse topologies in dynamic combinatorial libraries from tri- and mono-thiols in water: sensitivity to weak supramolecular interactions

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Publication details

The article was received on 12 Feb 2013, accepted on 05 Mar 2013 and first published on 14 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC41158C
Citation: Chem. Commun., 2013,49, 5820-5822

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    Diverse topologies in dynamic combinatorial libraries from tri- and mono-thiols in water: sensitivity to weak supramolecular interactions

    A. R. Stefankiewicz and J. K. M. Sanders, Chem. Commun., 2013, 49, 5820
    DOI: 10.1039/C3CC41158C

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