Issue 30, 2013
From the journal:

Chemical Communications

First enantioselective synthesis of tetracyclic intermediates en route to madangamine D†

Mercedes Amat,*a   Roberto Ballette,a   Stefano Proto,a   Maria Péreza  and  Joan Boscha  

* Corresponding authors

a Laboratory of Organic Chemistry, Faculty of Pharmacy, and Institute of Biomedicine (IBUB), University of Barcelona, 08028-Barcelona, Spain
E-mail: amat@ub.edu
Fax: +34 93 402 45 39
Tel: +34 93 402 45 40

Abstract

The enantioselective synthesis of advanced tetracyclic precursors of madangamine D, bearing rings ABCD of this alkaloid, is reported. The saturated 14-membered ring is assembled from functionalized diazatricyclic intermediates following either ring-closing metathesis or macrolactamization strategies.

Graphical abstract: First enantioselective synthesis of tetracyclic intermediates en route to madangamine D

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Article information

DOI
https://doi.org/10.1039/C3CC41104D
Article type
Communication
Submitted
08 Feb 2013
Accepted
28 Feb 2013
First published
01 Mar 2013

Chem. Commun., 2013,49, 3149-3151

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First enantioselective synthesis of tetracyclic intermediates en route to madangamine D

M. Amat, R. Ballette, S. Proto, M. Pérez and J. Bosch, Chem. Commun., 2013, 49, 3149 DOI: 10.1039/C3CC41104D

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