Issue 52, 2013
From the journal:

Chemical Communications

A vitamin-responsive mesoporous nanocarrier with DNA aptamer-mediated cell targeting†

Le-Le Li,‡ab   Mengying Xie,‡a   Jie Wang,a   Xinyang Li,a   Cheng Wang,a   Quan Yuan,*a   Dai-Wen Pang,*a   Yi Lu*b  and  Weihong Tancd  

* Corresponding authors

a Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
E-mail: yuanquan@whu.edu.cn, dwpang@whu.edu.cn

b Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
E-mail: yi-lu@illinois.edu

c Department of Chemistry and Department of Physiology and Functional Genomics, Shands Cancer Center and UF Genetics Institute, Center for Research at the Bio/Nano Interface, University of Florida, Gainesville, Florida 32611-7200, USA

d State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Biology, and College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

Abstract

A smart drug delivery system with cancer cell targeting and bioresponsive controlled drug release has been constructed by taking advantage of a protein-capped mesoporous nanovalve and a DNA aptamer.

Graphical abstract: A vitamin-responsive mesoporous nanocarrier with DNA aptamer-mediated cell targeting

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Article information

DOI
https://doi.org/10.1039/C3CC41072B
Article type
Communication
Submitted
07 Feb 2013
Accepted
04 Apr 2013
First published
05 Apr 2013

Chem. Commun., 2013,49, 5823-5825

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A vitamin-responsive mesoporous nanocarrier with DNA aptamer-mediated cell targeting

L. Li, M. Xie, J. Wang, X. Li, C. Wang, Q. Yuan, D. Pang, Y. Lu and W. Tan, Chem. Commun., 2013, 49, 5823 DOI: 10.1039/C3CC41072B

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