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Issue 30, 2013
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Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

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Abstract

Integration of the HIV cDNA into the host chromosome is a key event in the viral replication cycle. It is mediated by the viral integrase (IN) enzyme, which is an attractive anti-HIV drug target. Here we present the first AFM imaging of IN-mediated DNA integration products in a two-LTR system.

Graphical abstract: Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

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Article information


Submitted
29 Jan 2013
Accepted
20 Feb 2013
First published
21 Feb 2013

Chem. Commun., 2013,49, 3113-3115
Article type
Communication

Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

S. Guy, D. Rotem, Z. Hayouka, R. Gabizon, A. Levin, L. Zemel, A. Loyter, D. Porath and A. Friedler, Chem. Commun., 2013, 49, 3113
DOI: 10.1039/C3CC40748A

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