Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 30, 2013
Previous Article Next Article

Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

Author affiliations

Abstract

Integration of the HIV cDNA into the host chromosome is a key event in the viral replication cycle. It is mediated by the viral integrase (IN) enzyme, which is an attractive anti-HIV drug target. Here we present the first AFM imaging of IN-mediated DNA integration products in a two-LTR system.

Graphical abstract: Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

Back to tab navigation

Supplementary files

Article information


Submitted
29 Jan 2013
Accepted
20 Feb 2013
First published
21 Feb 2013

Chem. Commun., 2013,49, 3113-3115
Article type
Communication

Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

S. Guy, D. Rotem, Z. Hayouka, R. Gabizon, A. Levin, L. Zemel, A. Loyter, D. Porath and A. Friedler, Chem. Commun., 2013, 49, 3113
DOI: 10.1039/C3CC40748A

Social activity

Search articles by author

Spotlight

Advertisements