Issue 46, 2013
From the journal:

Chemical Communications

Hyperpolarization of amino acid precursors to neurotransmitters with parahydrogen induced polarization†

Pei Che Soon,‡a   Xiang Xu,‡a   Boyang Zhang,‡a   Francesca Gruppi,a   James W. Canary*a  and  Alexej Jerschow*a  

* Corresponding authors

a Chemistry Department, New York University, New York, NY 10003, USA
E-mail: alexej.jerschow@nyu.edu, canary@nyu.edu
Tel: +1-212-998-8451

Abstract

Several important neurotransmitter precursors were hyperpolarized via homogeneous hydrogenation with parahydrogen. Polarization enhancement was achieved for 1H and 13C spins by several orders of magnitude compared to thermal spectra. Such large signal enhancements of these molecules could facilitate neurotransmitter studies.

Graphical abstract: Hyperpolarization of amino acid precursors to neurotransmitters with parahydrogen induced polarization

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Article information

DOI
https://doi.org/10.1039/C3CC40426A
Article type
Communication
Submitted
17 Jan 2013
Accepted
21 Apr 2013
First published
23 Apr 2013

Chem. Commun., 2013,49, 5304-5306

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Hyperpolarization of amino acid precursors to neurotransmitters with parahydrogen induced polarization

P. C. Soon, X. Xu, B. Zhang, F. Gruppi, J. W. Canary and A. Jerschow, Chem. Commun., 2013, 49, 5304 DOI: 10.1039/C3CC40426A

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