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Issue 26, 2013
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pH-sensitive DNA cleaving agents: in situactivation by ring contraction of benzo-fused cyclobutanols

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Abstract

Benzo-fused cyclobutanols were developed as novel DNA cleaving molecules. The molecules nick a strand of supercoiled DNA under acidic conditions. By contrast, almost no activity was observed under neutral or basic conditions.

Graphical abstract: pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols

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Article information


Submitted
28 Dec 2012
Accepted
13 Feb 2013
First published
14 Feb 2013

Chem. Commun., 2013,49, 2622-2624
Article type
Communication

pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols

Y. Nagamoto, A. Hattori, H. Kakeya, Y. Takemoto and K. Takasu, Chem. Commun., 2013, 49, 2622
DOI: 10.1039/C3CC39246E

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