Qingwang Xue, Lei Wang and Wei Jiang
Chem. Commun., 2013,49, 2640-2642
DOI:
10.1039/C3CC39064K,
Communication
A novel label-free fluorescent sensing scheme for sensitive and selective detection of NAD+ and ATP has been developed based on dumbbell probe-mediated rolling circle amplification (D-RCA)-responsive G-quadruplex formation. This approach can detect 0.5 pM for ATP and 100 fM for NAD+, much lower than those of previously reported biosensors, and exhibits high discrimination ability.