Issue 37, 2013

Aptamer-targeted hyperbranched polymers: towards greater specificity for tumours in vivo

Abstract

Hyperbranched polymers conjugated to a peptide-aptamer were prepared using a combination of RAFT polymerisation and click chemistry for targeting tumour cells in vivo. The polymers showed enhanced cell-uptake in vitro (compared to unconjugated polymer) while excellent specificity for solid tumours was observed in vivo using a mouse model of melanoma.

Graphical abstract: Aptamer-targeted hyperbranched polymers: towards greater specificity for tumours in vivo

Supplementary files

Article information

Article type
Communication
Submitted
07 Jan 2013
Accepted
06 Feb 2013
First published
15 Feb 2013

Chem. Commun., 2013,49, 3836-3838

Aptamer-targeted hyperbranched polymers: towards greater specificity for tumours in vivo

D. J. Coles, B. E. Rolfe, N. R. B. Boase, R. N. Veedu and K. J. Thurecht, Chem. Commun., 2013, 49, 3836 DOI: 10.1039/C3CC00127J

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